Ipamorelin is a synthetic pentapeptide growth hormone secretagogue that has become a widely studied research peptide in the field of endocrine research. Unlike earlier growth hormone secretagogues, Ipamorelin was developed for its selectivity, stimulating GH release without the clinically relevant cortisol, prolactin, or ACTH elevation observed with other compounds. This article examines its research applications and the importance of sourcing from reliable peptides raw material manufacturers.
What Is Ipamorelin?
Ipamorelin is a pentapeptide with the sequence Aib-His-D-2-Nal-D-Phe-Lys-NH2 that acts as a selective ghrelin receptor (GHS-R1a) agonist. It is a growth hormone-releasing peptide that stimulates endogenous GH secretion by activating the ghrelin receptor.
Mechanism of Action
Ipamorelin stimulates GH release through the growth hormone secretagogue receptor type 1a (GHS-R1a). Its selectivity means it avoids the cortisol and prolactin elevation associated with earlier GHS compounds, making it a more refined tool for GH research.
Research Applications and Findings
– Bone Growth : Ipamorelin has been shown to induce longitudinal bone growth in rats.
– Muscle Research : When combined with CJC-1295, Ipamorelin showed significantly improved muscle strength in animal models.
– Regenerative Research : Ipamorelin is studied as a tool to reduce inflammation, accelerate healing, and optimize body composition.
Regulatory Status
Ipamorelin is prohibited by the World Anti-Doping Agency (WADA), exposing athletes to the risk of sanctions. As of April 2026, Ipamorelin is on the FDA 503A Category 2 bulk substances list and is not FDA-approved for any indication.
Research Applications
Ipamorelin is utilized in laboratory settings for growth hormone regulation and pulsatility studies, bone growth and development research, muscle preservation and recovery studies, and metabolic and body composition research.
Sourcing Ipamorelin for Research
When sourcing Ipamorelin from peptide raw material suppliers, verify:
– HPLC Purity : ≥98% with batch-specific chromatograms.
– Mass Confirmation : Verification of the correct molecular weight (approximately 711 Da).
– Sequence Confirmation : The pentapeptide sequence must be confirmed by MS/MS.
– Endotoxin Testing : Essential for in-vivo studies.
Product Disclaimer & Terms of Use
IMPORTANT NOTICE: FOR RESEARCH USE ONLY (RUO)
This product is intended exclusively for laboratory research and scientific development purposes. It is NOT a drug, food, medical device, cosmetic, or diagnostic product.