PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist that has been studied for its effects on sexual function and the melanocortin system. As a research peptide, PT-141 is of interest to scientists studying reproductive biology, neuroendocrinology, and the melanocortin system. This article examines its research applications and the importance of sourcing from reliable peptides raw material manufacturers.
What Is PT-141?
PT-141 is a synthetic cyclic peptide derived from Melanotan II. It was developed as a selective melanocortin receptor agonist with greater specificity for MC3R and MC4R receptors, which are involved in sexual function and energy homeostasis. Unlike Melanotan II, which primarily activates MC1R (pigmentation), PT-141 is designed to have reduced melanogenic effects.
Mechanism of Action
PT-141 exerts its effects through:
– MC3R/MC4R Activation : Modulates sexual function and desire.
– Central Nervous System Effects : Acts on hypothalamic and limbic pathways.
– Minimal MC1R Activation : Reduced pigmentation effects compared to Melanotan II.
Research Applications
PT-141 is utilized in laboratory settings for:
– Sexual function and reproductive research.
– Melanocortin receptor pharmacology.
– Neuroendocrine pathway studies.
– Appetite and energy metabolism research.
Regulatory Status
PT-141 (bremelanotide) was approved by the FDA in 2019 as an injectable treatment for hypoactive sexual desire disorder (HSDD) in premenopausal women under the brand name Vyleesi. However, research-grade PT-141 is distinct from the commercial pharmaceutical product and is labeled “For Research Use Only.”
Research Findings
Clinical and preclinical studies on PT-141 have demonstrated:
– Significant improvement in sexual desire in HSDD studies.
– Activation of MC3R and MC4R receptors.
– Potential effects on energy metabolism and appetite.
Sourcing PT-141 for Research
When sourcing PT-141 from peptide raw material suppliers, verify:
– HPLC Purity : ≥98% with batch-specific chromatograms.
– Mass Confirmation : Verification of the correct molecular weight (approximately 1,025 Da).
– Endotoxin Testing : Essential for in-vivo studies.
Quality Considerations
PT-141 is a cyclic peptide that requires careful synthesis and quality control. Look for peptide raw material suppliers who provide:
– Batch-specific COAs with full analytical data.
– Stability studies under recommended storage conditions.
– Confirmation of the cyclic structure.
Product Disclaimer & Terms of Use
IMPORTANT NOTICE: FOR RESEARCH USE ONLY (RUO)
This product is intended exclusively for laboratory research and scientific development purposes. It is NOT a drug, food, medical device, cosmetic, or diagnostic product.